Federer was set to play Jan-Lennard Struff of Germany and Williams faced Kristina Mladenovic of France as they continue their quests for a ninth and eighth Wimbledon title, respectively.
Williams finds herself the favorite again after defending champion Garbine Muguruza lost on Thursday, meaning only two of the top-eight seeded women are still in the field.
No. 3 Marin Cilic also lost on Thursday, becoming the third of the men’s top-10 seeds to go out.
Five-time champion Venus Williams was also in action, facing Kiki Bertens of the Netherlands.