There was no immediate word on casualties from the blast in the southern neighborhood of Qazaz, near the highway leading into central Damascus. State TV gave few details about the explosion, which happened on the first working day of the week, but said it appeared to have been “a terrorist act.”
State news agency SANA said the blast targeted a military checkpoint in the area, adding that nearby roads were closed. It added that a second attack in the same area was thwarted by security forces.
The Britain-based Syrian Observatory for Human Rights said the blast targeted a military intelligence department.
Attacks have been rare in Damascus since Syrian government forces captured the last rebel-held neighborhoods and suburbs of the capital last year.
Bombings had left hundreds dead over the course of the nearly eight-year civil war.